Nasopharyngeal infection byStreptococcus pyogenesrequires superantigen-responsive Vβ-specific T cells
نویسندگان
چکیده
منابع مشابه
Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive Vβ-specific T cells.
The globally prominent pathogen Streptococcus pyogenes secretes potent immunomodulatory proteins known as superantigens (SAgs), which engage lateral surfaces of major histocompatibility class II molecules and T-cell receptor (TCR) β-chain variable domains (Vβs). These interactions result in the activation of numerous Vβ-specific T cells, which is the defining activity of a SAg. Although strepto...
متن کاملEarly increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection.
Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. Here, we show in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen (SAg)-specific Foxp3(+) regulatory T cells (T(reg)) in Peyer's patches (PP). These increases were shown to be dependent on the presence...
متن کاملSuperantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus
Superantigens are defined by their ability to stimulate a large fraction of T cells via interaction with the T cell receptor (TCR) V beta domain. Endogenous superantigens, classically termed minor lymphocyte-stimulating (Mls) antigens, were recently identified as products of open reading frames (ORF) in integrated proviral copies of mouse mammary tumor virus (MMTV). We have described an infecti...
متن کاملInfluence of T cell receptor V alpha expression on Mlsa superantigen- specific T cell responses
Recognition of conventional foreign antigen by T cells is determined by the expression of multiple variable regions of both alpha and beta chains of the T cell receptor (TCR) alpha/beta heterodimer. In contrast, there exists a class of antigens that appears to interact with the TCR alpha/beta heterodimer through the variable region on the beta chain (V beta), independent of other TCR components...
متن کاملInfluence of T Cell Receptor Expression on Mls a Superantigen-specific T Cell Responses
Recognition of conventional foreign antigen by T cells is determined by the expression of multiple variable regions of both ol and 3 chains of the T cell receptor (TCR) oe/3 heterodimer. In contrast, there exists a class of antigens that appears to interact with the TCR c~/3 heterodimer through the variable region on the 3 chain (V3), independent of other TCR components, a property that has led...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1700858114